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padding-left: 15px; padding-right: 15px; padding-top: 10px;"> <table cellpadding="0" cellspacing="0" border="0" align="left" width="100%"> <tr> <td align="left" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 10px; font-weight: normal; line-height: 1.4;">$PRE_HEADER$</td> <td align="right" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 10px; font-weight: normal; line-height: 1.4; width: 100px;"><a href="#" target="_blank" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;">View online</a></td> </tr> </table> </td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" class="email-gutter-mobile-10"> <table cellpadding="0" cellspacing="0" border="0" width="100%"> <tr> <td align="center" class="mpb-12" style="padding-bottom: 8px; padding-top: 16px;"> <table border="0" cellpadding="0" cellspacing="0"> <tr> <td align="center" valign="middle" class="mfs-11" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 12px; font-weight: normal; line-height: 1.4; padding: 0 5px 0 0;"><a href="https://www.novomedlink.com/rare-bleeding-disorders/products/treatments/alhemo.html?tc=em_wq4kv0m&cc=5003&utm_medium=email&utm_source=iqva&utm_campaign=alhemo_promotional&utm_content=product_information_us25ahm00183&showisi=true" target="_blank" style="color: #7A4BFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;">Important Safety Information</a></td> <td align="center" style="color: #4a4a4a; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 12px; font-weight: normal; line-height: 1.4;"> | </td> <td align="center" valign="middle" class="mfs-11" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 12px; font-weight: normal; line-height: 1.4; padding: 0 0 0 5px;"> <a href="https://www.novo-pi.com/alhemo.pdf?tc=em_wq4kv0m&cc=5003&utm_medium=email&utm_source=iqva&utm_campaign=alhemo_promotional&utm_content=product_information_us25ahm00183" target="_blank" style="color: #7A4BFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;">Prescribing Information</a></td> </tr> </table> </td> </tr> <tr> <td align="center" style="padding-bottom: 4px;"><a href="https://www.novomedlink.com/rare-bleeding-disorders/products/treatments/alhemo.html?tc=em_wq4kv0m&cc=5003&utm_medium=email&utm_source=iqva&utm_campaign=alhemo_promotional&utm_content=product_information_us25ahm00183" target="_blank" style="color: #7A4BFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;"><img src="https://emails.hemo.novo.cglife.dev/emails/alhemo-hcp-hem-b-cpd/images/alhemo-logo.png" width="160" height="90" border="0" alt="Logo for Alhemo® (concizumab-mtci) injection 60 mg, 150 mg, or 300 mg" style="display: inline-block;"></a></td> </tr> </table> </td> </tr> <tr> <td align="center" class="email-gutter-80" style="padding-left: 80px; padding-right: 80px;"> <table cellpadding="0" cellspacing="0" border="0" width="100%"> <tr> <td align="center" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-style: italic; font-weight: normal; line-height: 18px; padding-bottom: 16px;">Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup> (concizumab-mtci) injection 60 mg, 150 mg, or 300 mg is indicated for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients 12 years of age and older with hemophilia A or B with or without Factor VIII or IX inhibitors.</td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" style="background-color: #7A4BFF;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 12px; font-weight: bold; line-height: 14px; padding-bottom: 8px; padding-top: 8px;"><a href="https://www.novomedlink.com/account/create.html?tc=em_wq4kv0m&cc=5003&utm_medium=email&utm_source=iqva&utm_campaign=alhemo_promotional&utm_content=product_information_us25ahm00183" target="_blank" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;">Sign up</a> to stay in the know</td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center"> <img src="https://emails.hemo.novo.cglife.dev/emails/alhemo-hcp-hem-b-cpd/images/hero.png" width="670" height="347" border="0" alt="Photo of a diver perched on an Alhemo® pen, ready to jump, with text that reads: 'More than a pen— A springboard to everyday bleed protection(1) Adherence to daily dosing of Alhemo® is important to maintain protection against bleeding.'" class="mobile-hide" style="display: block;"> <!--[if !mso]><!--> <div class="mobile-only-content" style="display: none; max-height: 0; max-width: 0; visibility: hidden; width: 0;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td class="email-gutter mpt-20" style="padding-left: 30px; padding-right: 30px;"> <table cellpadding="0" cellspacing="0" border="0" width="100%"> <tr> <td align="left" style="color: #7A4BFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 26px; font-weight: normal; line-height: 32px;">More than a pen—</td> </tr> <tr> <td align="left" style="color: #7A4BFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 35px; font-weight: normal; line-height: 44px;">A springboard to</td> </tr> <tr> <td align="left" style="color: #7A4BFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 35px; font-weight: normal; line-height: 44px; padding-bottom: 16px;"><b>everyday bleed protection</b><sup style="font-size: 60%; line-height: 1;">1</sup></td> </tr> <tr> <td align="left" style="color: #7A4BFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 10px; font-weight: normal; line-height: 14px; padding-bottom: 8px;">Adherence to daily dosing of Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup> is important to maintain protection against bleeding.</td> </tr> </table> </td> </tr> </table> <table cellpadding="0" cellspacing="0" border="0" width="100%"> <tr> <td align="center" valign="top"><img src="https://emails.hemo.novo.cglife.dev/emails/alhemo-hcp-hem-b-cpd/images/hero-mobile.png" width="750" height="576" border="0" alt="Photo of a diver perched on an Alhemo® pen, ready to jump." class="img-responsive" style="display: block; max-width: 610px;"></td> </tr> </table> </div> <!--<![endif]--> </td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" class="mpb-32" style="background-color: #93ECFC; padding-bottom: 40px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" class="email-gutter-100" style="padding-left: 100px; padding-right: 100px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" class="mfs-16 mlh-24 mpt-16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 26px; padding-bottom: 24px; padding-top: 8px;">Routine prophylaxis treatment in a prefilled, subcutaneous pen for patients 12 and older with <strong>hemophilia B and A with or without inhibitors.</strong> </td> </tr> <tr> <td align="center" style="padding-bottom: 24px;"><a href="https://www.novomedlink.com/rare-bleeding-disorders/products/treatments/alhemo/about/pen.html?tc=em_wq4kv0m&cc=5003&utm_medium=email&utm_source=iqva&utm_campaign=alhemo_promotional&utm_content=product_information_us25ahm00183" target="_blank" style="background-color: #fbb03b; border-radius: 50px; color: #001965; display: inline-block; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 20px; mso-padding-alt: 0; padding-bottom: 15px; padding-left: 25px; padding-right: 25px; padding-top: 15px; text-decoration: none; text-underline-color: #fbb03b;"><!--[if mso]><i style="mso-font-width:150%; mso-text-raise:140%;" hidden> </i><span style="mso-text-raise:70%;"><![endif]-->Get to know Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup><!--[if mso]></span><i style="mso-font-width:150%;" hidden> ​</i><![endif]--></a> </td> </tr> <tr> <td align="center" class="text-left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 10px; font-weight: normal; line-height: 14px; padding-bottom: 2px;">Actor portrayal. Needles sold separately and may require a prescription in some states.</td> </tr> </table> </td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" height="10" style="height: 10px; line-height: 10px; background-color: #ffffff;"> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" class="email-gutter" style="background-color: #7A4BFF; padding-bottom: 12px; padding-left: 30px; padding-right: 30px; padding-top: 12px;"> <table cellpadding="0" cellspacing="0" border="0" width="100%"> <tr> <td align="center" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-weight: normal; line-height: 1.4; padding-bottom: 8px;">Keep scrolling to learn more about Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup></td> </tr> <tr> <td align="center" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-weight: normal; line-height: 1.4;"><img src="https://emails.hemo.novo.cglife.dev/emails/alhemo-hcp-hem-b-cpd/images/arrow.png" width="50" height="26" alt style="display: block;"></td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" class="email-gutter" style="padding-bottom: 32px; padding-left: 30px; padding-right: 30px; padding-top: 30px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center"> <table cellpadding="0" cellspacing="0" border="0" width="100%"> <tr> <td align="left" style="color: #7A4BFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 22px; font-weight: normal; line-height: 26px; padding-bottom: 20px;">Important Safety Information</td> </tr> <tr> <td align="left" style="color: #7A4BFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 20px; padding-bottom: 12px;">Contraindications</td> </tr> <tr> <td align="left" style="padding-bottom: 20px;"> <table border="0" cellpadding="0" cellspacing="0"> <tr> <td align="center" valign="top" width="20" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px;">•</td> <td width="5"> </td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px;">Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup> is contraindicated in patients with a history of known serious hypersensitivity to Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup> or its ingredients</td> </tr> </table> </td> </tr> <tr> <td align="left" style="color: #7A4BFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 20px; padding-bottom: 12px;">Warnings and Precautions</td> </tr> <tr> <td align="left" style="padding-bottom: 16px;"> <table border="0" cellpadding="0" cellspacing="0"> <tr> <td align="center" valign="top" width="20" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px;">•</td> <td width="5"> </td> <td align="left"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px;"><b>Thromboembolic Events (TEs):</b> Venous and arterial TEs were reported in 1.9% of patients (6/320) who also had multiple risk factors, including the use of high doses or prolonged treatment with factor product or bypassing agent (2 of 6 patients). Risk factors for TEs may also include conditions in which tissue factor is overexpressed (eg, atherosclerotic disease, crush injury, cancer, disseminated intravascular coagulation, thrombotic microangiopathy, or septicemia). Inform patients about and monitor them for signs and symptoms of TEs. In case of suspicion of TEs, discontinue Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup> and initiate further investigations and management strategies</td> </tr> </table> </td> </tr> </table> </td> </tr> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 1.4; padding-bottom: 16px;">Please <a href="https://www.novomedlink.com/rare-bleeding-disorders/products/treatments/alhemo.html?showisi=true&tc=em_wq4kv0m&cc=5003&utm_medium=email&utm_source=iqva&utm_campaign=alhemo_promotional&utm_content=product_information_us25ahm00183" target="_blank" style="color: #025edc; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;">click here</a> or scroll below for additional Important Safety Information.</td> </tr> </table> </td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="left" style="background-color: #DBF5FF;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" class="mobile-hide"> <img src="https://emails.hemo.novo.cglife.dev/emails/alhemo-hcp-hem-b-cpd/images/quote-photo.jpg" width="240" height="212" alt="Photo of Royal smiling with the following caption: ‘Royal lives with hemophilia B with inhibitors, uses Alhemo®, and is an employee of Novo Nordisk.’" class="mobile-hide" style="display: block; padding-top: 28px;"> </td> <td class="email-gutter-25 mpt-36" style="padding-bottom: 20px; padding-left: 25px; padding-right: 25px; padding-top: 30px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" style="color: #5433B0; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-style: italic; font-weight: bold; line-height: 22px; padding-bottom: 12px;">“Because it is prefilled and doesn’t need mixing, the Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup> pen is ready when I need it. I find the administration easy, so I can have daily bleed protection.”</td> </tr> <tr> <td align="left" class="mpb-12" style="color: #5433B0; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 10px; font-weight: normal; line-height: 14px;">—<b>Royal</b> lives with hemophilia B with inhibitors, uses Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup>, and is an employee of Novo Nordisk</td> </tr> <tr> <td align="left" class="mpb-12" style="color: #5433B0; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 9px; font-weight: normal; line-height: 14px; padding-top: 24px;">Adherence to daily dosing of Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup> is important to maintain protection against bleeding.</td> </tr> </table> </td> </tr> </table> <!--[if !mso]><!--> <div class="mobile-only-content" style="display: none; max-height: 0; max-width: 0; visibility: hidden; width: 0;"> <table cellpadding="0" cellspacing="0" border="0" width="100%"> <tr> <td align="center"><img src="https://emails.hemo.novo.cglife.dev/emails/alhemo-hcp-hem-b-cpd/images/quote-photo-mobile.jpg" width="750" height="380" border="0" alt="Photo of Royal smiling with the following caption: ‘Royal lives with hemophilia B with inhibitors, uses Alhemo®, and is an employee of Novo Nordisk.’" class="img-responsive" style="display: block; max-width: 610px;"></td> </tr> </table> </div> <!--<![endif]--> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #7A4BFF; width: 670px;"> <tr> <td align="center" class="email-gutter-80 mpt-52" style="padding-left: 80px; padding-right: 80px; padding-top: 40px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" style="padding-bottom: 24px;"><img src="https://emails.hemo.novo.cglife.dev/emails/alhemo-hcp-hem-b-cpd/images/icon-prepare.png" width="100" height="70" alt style="display: block;"></td> </tr> <tr> <td align="center" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 26px; font-weight: bold; line-height: 32px; padding-bottom: 2px;">90 seconds to prepare and administer.</td> </tr> <tr> <td align="center" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 26px; font-weight: normal; line-height: 32px; padding-bottom: 16px;">~6 seconds to inject.<sup style="font-size: 60%; line-height: 1;">1,2,a</sup></td> </tr> <tr> <td align="center" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 24px; padding-bottom: 16px;">The Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup> prefilled pen was rated as both easy to use (98%, n=78) and easy to learn to use (97%, n=78).<sup style="font-size: 70%; line-height: 1;">1,2,b</sup></td> </tr> <tr> <td align="center" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 12px; font-weight: normal; line-height: 16px; padding-bottom: 28px;"><a href="https://www.novo-pi.com/alhemo.pdf?tc=em_wq4kv0m&cc=5003&utm_medium=email&utm_source=iqva&utm_campaign=alhemo_promotional&utm_content=product_information_us25ahm00183#page=6" target="_blank" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;">Read IFU</a> for full administration instructions.</td> </tr> <tr> <td align="center" style="padding-bottom: 32px;"><a href="https://www.novomedlink.com/rare-bleeding-disorders/products/treatments/alhemo/about/pen.html?tc=em_wq4kv0m&cc=5003&utm_medium=email&utm_source=iqva&utm_campaign=alhemo_promotional&utm_content=product_information_us25ahm00183#easy" target="_blank" style="background-color: #FBB03B; border-radius: 40px; color: #001965; display: inline-block; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-weight: bold; line-height: 16px; mso-padding-alt: 0; padding-bottom: 10px; padding-left: 30px; padding-right: 30px; padding-top: 10px; text-decoration: none; text-underline-color: #FBB03B;"><!--[if mso]><i style="mso-font-width:150%; mso-text-raise:140%;" hidden> </i><span style="mso-text-raise:70%;"><![endif]-->Discover what’s possible<!--[if mso]></span><i style="mso-font-width:150%;" hidden> ​</i><![endif]--></a> </td> </tr> </table> </td> </tr> <tr> <td align="center" class="email-gutter mpb-48" style="padding-bottom: 40px; padding-left: 30px; padding-right: 30px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 10px; font-weight: normal; line-height: 14px; padding-bottom: 2px;"><sup style="font-size: 70%; line-height: 1;">a</sup>After the dose counter is at “0,” count slowly to 6 while the needle is still in skin.</td> </tr> <tr> <td align="left" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 10px; font-weight: normal; line-height: 14px; padding-bottom: 16px;"><sup style="font-size: 70%; line-height: 1;">b</sup>Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup> is intended for use under the guidance of healthcare provider, and may be self-administered or administered by a caregiver after appropriate training and reading the Instructions for Use, if a healthcare provider determines that is appropriate.</td> </tr> <tr> <td align="left" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 12px; font-weight: normal; line-height: 16px;"><b>Study design:</b> A device handling study of the Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup> pen that included 80 participants: 65 patients (44 adults, 21 adolescents) with hemophilia A or B, with or without inhibitors, using factor replacement or FVIII mimetic therapy (51% on factor, 49% on FVIII mimetic), and 15 caregivers. The main objectives were to determine whether the concizumab pen-injector is easy to learn how to use and easy to use using the Hemophilia Device Handling and Preference Assessment questionnaire. After training, participants independently prepared and performed a single pen injection, administering into an injection pad or manikin. An injection was complete if participant could attach needle, remove outer and inner caps, and set and inject intended dose. Time for training, preparation, injections, and number of complete injections were assessed. Average time to complete an injection was 1 min, 21 sec. Survey rating scale included: Very Difficult, Difficult, Neither difficult nor easy, Easy, and Very easy. Limitations: simulated use models may not completely reflect experience of at-home use. In addition, it may be difficult for a participant to evaluate the pen-injector based on a single simulated injection.</td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container mobile-hide" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" height="10" style="height: 10px; line-height: 10px; background-color: #ffffff;"> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #DBF5FF; width: 670px;"> <tr> <td align="center" class="email-gutter-50 mpt-36 mpb-40" style="padding-bottom: 56px; padding-left: 50px; padding-right: 50px; padding-top: 56px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" valign="top" class="responsive-td"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" class="mpt-10 text-center" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 22px; font-weight: bold; line-height: 28px; padding-bottom: 30px; padding-top: 40px;">Have questions? <br>We’re here to help.</td> </tr> <tr> <td align="left" class="mpb-30"><a href="https://www.novomedlink.com/rare-bleeding-disorders/products/resources/novonordisk-representative.html?tc=em_wq4kv0m&cc=5003&utm_medium=email&utm_source=iqva&utm_campaign=alhemo_promotional&utm_content=product_information_us25ahm00183" target="_blank" style="background-color: #DBF5FF; border: 2px solid #001965; border-radius: 40px; color: #001965; display: inline-block; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-weight: bold; line-height: 16px; mso-padding-alt: 0; padding-bottom: 10px; padding-left: 25px; padding-right: 25px; padding-top: 10px; text-decoration: none; text-underline-color: #DBF5FF;"><!--[if mso]><i style="mso-font-width:150%; mso-text-raise:140%;" hidden> </i><span style="mso-text-raise:70%;"><![endif]-->Contact your rep<!--[if mso]></span><i style="mso-font-width:150%;" hidden> ​</i><![endif]--></a> </td> </tr> </table> </td> <td align="center" valign="top" width="280" style="width: 280px;" class="responsive-td"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" class="text-center" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-weight: normal; line-height: 20px; padding-bottom: 20px;">Connect with a Novo Nordisk Rare Blood Therapy Manager in your area. They can help you with:</td> </tr> <tr> <td align="center"> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="max-width: 320px;"> <tr> <td align="left" valign="top" width="30" style="padding-bottom: 10px; width: 30px;"><img src="https://emails.hemo.novo.cglife.dev/emails/alhemo-hcp-hem-b-cpd/images/checkmark.png" width="20" height="20" alt style="display: block;"></td> <td align="left" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-weight: normal; line-height: 20px; padding-bottom: 10px;">Clinical product information</td> </tr> <tr> <td align="left" valign="top" width="30" style="padding-bottom: 10px; width: 30px;"><img src="https://emails.hemo.novo.cglife.dev/emails/alhemo-hcp-hem-b-cpd/images/checkmark.png" width="20" height="20" alt style="display: block;"></td> <td align="left" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-weight: normal; line-height: 20px; padding-bottom: 10px;">Rare bleeding education for patients</td> </tr> <tr> <td align="left" valign="top" width="30" style="padding-bottom: 10px; width: 30px;"><img src="https://emails.hemo.novo.cglife.dev/emails/alhemo-hcp-hem-b-cpd/images/checkmark.png" width="20" height="20" alt style="display: block;"></td> <td align="left" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-weight: normal; line-height: 20px; padding-bottom: 10px;">Resources for starting treatment</td> </tr> <tr> <td align="left" valign="top" width="30" style="padding-bottom: 10px; width: 30px;"><img src="https://emails.hemo.novo.cglife.dev/emails/alhemo-hcp-hem-b-cpd/images/checkmark.png" width="20" height="20" alt style="display: block;"></td> <td align="left" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-weight: normal; line-height: 20px; padding-bottom: 10px;">General questions & inquiries</td> </tr> </table> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" height="10" style="height: 10px; line-height: 10px; background-color: #ffffff;"> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #001965; width: 670px;"> <tr> <td align="center" class="email-gutter-80" style="padding-bottom: 40px; padding-left: 80px; padding-right: 80px; padding-top: 40px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" class="mpb-16" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 20px; font-weight: bold; line-height: 28px; padding-bottom: 28px;">Do you have a novoMEDLINK™ account?</td> </tr> <tr> <td align="center" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 22px; padding-bottom: 28px;">Complete a simple registration to receive the latest product news and education from Novo Nordisk.</td> </tr> <tr> <td align="center" style="padding-bottom: 24px;"><a href="https://www.novomedlink.com/account/create.html?tc=em_wq4kv0m&cc=5003&utm_medium=email&utm_source=iqva&utm_campaign=alhemo_promotional&utm_content=product_information_us25ahm00183" target="_blank" style="background-color: #ffffff; border-radius: 40px; color: #001965; display: inline-block; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-weight: bold; line-height: 16px; mso-padding-alt: 0; padding-bottom: 10px; padding-left: 30px; padding-right: 30px; padding-top: 10px; text-decoration: none; text-underline-color: #ffffff;"><!--[if mso]><i style="mso-font-width:150%; mso-text-raise:140%;" hidden> </i><span style="mso-text-raise:70%;"><![endif]-->Register<!--[if mso]></span><i style="mso-font-width:150%;" hidden> ​</i><![endif]--></a> </td> </tr> <tr> <td align="center" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 22px; padding-bottom: 28px;">With a novoMEDLINK™ account you can:</td> </tr> <tr> <td align="center" class="email-gutter-mobile-20"> <table border="0" cellpadding="0" cellspacing="0" class="col-280" style="width: 280px;"> <tr> <td width="50" style="width: 50px;" align="left" valign="middle"><img src="https://emails.hemo.novo.cglife.dev/emails/alhemo-hcp-hem-b-cpd/images/icon-book.png" width="30" height="40" alt style="display: block;"></td> <td align="left" valign="middle" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 22px;">Order educational materials</td> </tr> <tr> <td width="50" height="20" style="width: 50px; height: 20px; line-height: 20px;"> </td> <td height="20" style="height: 20px; line-height: 20px;"> </td> </tr> <tr> <td width="50" style="width: 50px;" align="left" valign="middle"><img src="https://emails.hemo.novo.cglife.dev/emails/alhemo-hcp-hem-b-cpd/images/icon-list-bullets.png" width="30" height="30" alt style="display: block;"></td> <td align="left" valign="middle" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 22px;">Access the latest product information</td> </tr> <tr> <td width="50" height="20" style="width: 50px; height: 20px; line-height: 20px;"> </td> <td height="20" style="height: 20px; line-height: 20px;"> </td> </tr> <tr> <td width="50" style="width: 50px;" align="left" valign="middle"><img src="https://emails.hemo.novo.cglife.dev/emails/alhemo-hcp-hem-b-cpd/images/icon-updates.png" width="30" height="36" alt style="display: block;"></td> <td align="left" valign="middle" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 22px;">Receive personalized updates</td> </tr> </table> </td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" class="email-gutter mpt-40" style="padding-bottom: 28px; padding-left: 30px; padding-right: 30px; padding-top: 36px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center"> <table cellpadding="0" cellspacing="0" border="0" width="100%"> <tr> <td align="left" style="color: #7A4BFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 22px; font-weight: normal; line-height: 26px; padding-bottom: 16px;">Indications and Usage for Alhemo<sup style="font-size: 60%; line-height: 1;">®</sup></td> </tr> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; padding-bottom: 28px;">Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup> (concizumab-mtci) injection 60 mg, 150 mg, or 300 mg is indicated for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients 12 years of age and older with hemophilia A or B with or without Factor VIII or IX inhibitors.</td> </tr> <tr> <td align="left" style="color: #7A4BFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 22px; font-weight: normal; line-height: 26px; padding-bottom: 20px;">Important Safety Information (cont’d)</td> </tr> <tr> <td align="left" style="color: #7A4BFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 20px; padding-bottom: 12px;">Warnings and Precautions (cont'd)</td> </tr> <tr> <td align="left" style="padding-bottom: 20px;"> <table border="0" cellpadding="0" cellspacing="0"> <tr> <td align="center" valign="top" width="20" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; width: 20px;">•</td> <td width="5" style="width: 5px;"> </td> <td align="left"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px;"><b>Hypersensitivity Reactions:</b> Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup> is contraindicated in patients with a history of known serious hypersensitivity to Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup> or its ingredients. Hypersensitivity reactions, including erythema, rash, pruritus, and abdominal pain, have occurred in patients treated with Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup>. One patient (<1%) experienced anaphylaxis, which resolved after treatment with antihistamines and corticosteroids. Instruct patients of the signs of acute hypersensitivity reactions and to contact their healthcare provider for mild reactions and to seek urgent medical attention for moderate to severe reactions. Discontinue Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup> if severe hypersensitivity symptoms occur and initiate medical management</td> </tr> </table> </td> </tr> <tr> <td align="center" valign="top" width="20" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; width: 20px;">•</td> <td width="5" style="width: 5px;"> </td> <td align="left"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px;"><b>Increased Laboratory Values of Fibrin D-dimer and Prothrombin Fragment 1.2:</b> Increased levels of fibrin D-dimer and prothrombin fragment 1.2 were seen in 29 (9.1%) and 26 (8.1%) patients, respectively, which is positively correlated with the plasma concentration of concizumab-mtci, indicating a hemostatic effect. For patients taking Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup>, these coagulation biomarkers may not be reliable predictive markers for clinical decision-making with suspicion of thrombosis, such as deep vein thrombosis and pulmonary embolism</td> </tr> </table> </td> </tr> </table> </td> </tr> <tr> <td align="left" style="color: #7A4BFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 1.4; padding-bottom: 12px;">Adverse Reactions</td> </tr> <tr> <td align="left" style="padding-bottom: 20px;"> <table border="0" cellpadding="0" cellspacing="0"> <tr> <td align="center" valign="top" width="20" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; width: 20px;">•</td> <td width="5" style="width: 5px;"> </td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px;">The most frequently reported adverse reactions (≥5%) were injection site reactions, headache, and urticaria</td> </tr> <tr> <td align="center" valign="top" width="20" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; width: 20px;">•</td> <td width="5" style="width: 5px;"> </td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px;">Serious adverse reactions were reported in 6.1% of patients with inhibitors who received Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup>. Permanent discontinuation of Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup> occurred in 1 patient due to a renal infarct and dosage interruptions of Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup> occurred in 1 patient (3%) and was a hypersensitivity reaction</td> </tr> </table> </td> </tr> <tr> <td align="left" style="color: #7A4BFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 1.4; padding-bottom: 12px;">Drug Interactions</td> </tr> <tr> <td align="left" style="padding-bottom: 20px;"> <table border="0" cellpadding="0" cellspacing="0"> <tr> <td align="center" valign="top" width="20" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; width: 20px;">•</td> <td width="5" style="width: 5px;"> </td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px;"><b>Breakthrough Bleeding Treatment:</b> Take appropriate precautions when treating breakthrough bleeding events in patients receiving Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup> prophylaxis and FVIII or FIX or a bypassing agent (eg, rFVIIa or aPCC). For mild and moderate bleeds, the lowest approved dose in the approved product labeling is recommended. For aPCC, a maximum dose of 100 units/kg within 24 hours is recommended. For severe bleeds, follow the dosing instructions in the approved labeling based on clinical judgment</td> </tr> </table> </td> </tr> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 1.4; padding-bottom: 12px;">Please <a href="https://www.novo-pi.com/alhemo.pdf?tc=em_wq4kv0m&cc=5003&utm_medium=email&utm_source=iqva&utm_campaign=alhemo_promotional&utm_content=product_information_us25ahm00183" target="_blank" style="color: #025edc; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;">click here</a> for Prescribing Information.</td> </tr> </table> </td> </tr> </table> </td> </tr> <tr> <td align="left" class="email-gutter" style="padding-bottom: 16px; padding-left: 30px; padding-right: 30px;"> <table cellspacing="0" cellpadding="0" border="0" width="100%"> <tr> <td align="left" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 12px; font-weight: normal; line-height: 1.4; padding-bottom: 12px;"><b>References:</b></td> </tr> </table> <table cellspacing="0" cellpadding="0" border="0" width="100%"> <tr> <td width="20" align="left" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px;">1.</td> <td align="left" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px;"><span class="default-blue-text">Alhemo [Prescribing Information]. Novo Nordisk Inc.</span></td> </tr> <tr> <td width="20" align="left" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px;">2.</td> <td align="left" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px;"><span class="default-blue-text">Rasmussen NK, Berg B, Christiansen ASL, et al. The concizumab pen-injector is easy to use and preferred by hemophilia patients and caregivers: a usability study assessing pen-injector handling and preference. <i>Patient Prefer Adherence</i>. 2024:18 1713-1727.</span></td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" class="email-gutter" style="padding-bottom: 20px; padding-left: 30px; padding-right: 30px; padding-top: 20px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td valign="top"> <table cellpadding="0" cellspacing="0" border="0" width="100%" style="border-top: 1px solid #979797"> <!-- Pricing Block Start --> <tr> <td align="left" class="pricing-block-text" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-style: italic; font-weight: bold; line-height: 18px; padding-bottom: 20px; padding-top: 25px;"> Please click on the link to see WAC pricing for the product mentioned above: <a href="https://www.novopricing.com/alhemo.html?tc=em_wq4kv0m&cc=5003&utm_medium=email&utm_source=iqva&utm_campaign=alhemo_promotional&utm_content=product_information_us25ahm00183" style="color: #025edc; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;" target="_blank">Product Pricing</a>. </td> </tr> <!--Pricing Block End --> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 12px; font-weight: normal; line-height: 16px;">Please do not respond to this email. 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To better understand how Novo Nordisk values your privacy, see our <a href="https://www.novonordisk-us.com/privacy-notice.html?tc=em_wq4kv0m&cc=5003&utm_medium=email&utm_source=iqva&utm_campaign=alhemo_promotional&utm_content=product_information_us25ahm00183" target="_blank" style="color: #025edc; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;">Privacy Statement</a>.</span></td> </tr> </table> </td> </tr> <tr> <td valign="bottom" style="padding-bottom: 20px; padding-top: 20px;"> <table cellpadding="0" cellspacing="0" border="0" align="left" width="100%"> <tr> <td align="left" valign="bottom" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 16px;"><span class="grey-text">Alhemo<sup style="font-size: 70%; line-height: 1;">®</sup> is a registered trademark of Novo Nordisk Health Care AG.<br>novoMEDLINK™ is a trademark of Novo Nordisk A/S.<br>Novo Nordisk is a registered trademark of Novo Nordisk A/S.<br>© 2025 Novo Nordisk All rights reserved. <span style="white-space: nowrap;">US25AHM00183</span> <span style="white-space: nowrap;">August 2025</span></span></td> <td align="right" valign="bottom" class="col-80 mobile-hide" style="width: 80px;"><img src="https://emails.hemo.novo.cglife.dev/emails/alhemo-hcp-hem-b-cpd/images/logo-novo-nordisk.png" width="75" height="55" alt="Novo Nordisk logo." style="display: block;"></td> </tr> </table> <!--[if !mso]><!--> <div class="mobile-only-content" style="display: none; max-height: 0; max-width: 0; visibility: hidden; width: 0;"> <table cellpadding="0" cellspacing="0" border="0" width="100%"> <tr> <td align="center" valign="top" style="padding-top: 20px;"><img src="https://emails.hemo.novo.cglife.dev/emails/alhemo-hcp-hem-b-cpd/images/logo-novo-nordisk.png" width="75" height="55" alt="Novo Nordisk logo." style="display: block;"></td> </tr> </table> </div> <!--<![endif]--> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> </center> </body> </html>