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<!DOCTYPE html> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office"> <head> <title>Novo Nordisk</title> <meta http-equiv="Content-Type" content="text/html; charset=utf-8"> <meta name="viewport" content="width=device-width"> <!--[if gte mso 9]><xml> <o:OfficeDocumentSettings> <o:AllowPNG/> <o:PixelsPerInch>96</o:PixelsPerInch> </o:OfficeDocumentSettings> </xml><![endif]--> <!--[if (gte mso 15)|(IE)]> <style type="text/css"> table { border-collapse: collapse; border-spacing: 0; mso-line-height-rule: exactly; mso-margin-bottom-alt: 0; mso-margin-top-alt: 0; mso-table-lspace: 0pt; mso-table-rspace: 0pt;} td {mso-hyphenate: none;} </style> <![endif]--> <!--[if gte mso 9]> <style> sup, sub { font-size: 100% !important; } </style> <![endif]--> <style type="text/css"> @media screen { @font-face { font-family: 'Noto Sans'; font-style: italic; font-weight: 400 900; font-stretch: 100%; font-display: fallback; src: url('https://fonts.gstatic.com/s/notosans/v38/o-0ZIpQlx3QUlC5A4PNr4C5OaxRsfNNlKbCePevtuXOmHS91iw.woff2') format('woff2'); 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width: 670px;"> <tr> <td align="center" class="email-gutter-desktop-only" style="padding-left: 30px; padding-right: 30px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="border-bottom: 1px solid #E5E3E6;"> <tr> <td valign="top" class="email-gutter-15" style="padding-bottom: 10px; padding-left: 15px; padding-right: 15px; padding-top: 10px;"> <table cellpadding="0" cellspacing="0" border="0" align="left" width="100%"> <tr> <td align="left" valign="top" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 10px; font-weight: normal; line-height: 12px;"> <!-- Preheader text --> <div style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 10px; font-weight: normal; line-height: 12px;"></div> <!-- Preheader filler spaces --> <div style="display: none; max-height: 0; max-width: 0; width: 0; visibility: hidden; overflow: hidden; font-size: 1px; line-height: 0; mso-hide: all;">  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ </div> </td> <td align="right" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 10px; font-weight: normal; line-height: 12px; width: 100px;"><a href="https://example.com/view-online" target="_blank" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;">View online</a></td> </tr> </table> </td> </tr> </table> </td> </tr> <tr> <td align="center" class="email-gutter-desktop-only" style="padding-left: 30px; padding-right: 30px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td valign="top" class="email-gutter-mobile-10"> <table cellpadding="0" cellspacing="0" border="0" width="100%"> <tr> <td align="center" class="mpt-8" style="padding-bottom: 12px; padding-top: 16px;"> <table border="0" cellpadding="0" cellspacing="0"> <tr> <th align="center" valign="middle" class="mfs-11" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 12px; font-weight: normal; line-height: 1.4; padding-bottom: 4px; padding-top: 4px;"><a href="https://www.novomedlink.com/rare-bleeding-disorders/products/treatments/frehemgo.html?showisi=true" target="_blank" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;">Important Safety Information</a></th> <th align="center" style="color: #4a4a4a; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 12px; font-weight: normal; line-height: 1.4; padding-bottom: 4px; padding-top: 4px;"> | </th> <th align="center" valign="middle" class="mfs-11" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 12px; font-weight: normal; line-height: 1.4; padding-bottom: 4px; padding-top: 4px;"><a href="https://www.novo-pi.com/frehemgo.pdf" target="_blank" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;">Prescribing Information</a></th> </tr> </table> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" class="email-gutter-desktop-only" style="padding-bottom: 24px; padding-left: 30px; padding-right: 30px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" class="email-gutter-mobile-only" style="padding-bottom: 8px; padding-left: 0; padding-right: 0;"><a href="https://www.novomedlink.com/rare-bleeding-disorders/products/treatments/frehemgo.html" target="_blank" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;"><img src="https://emails.hemo.novo.cglife.dev/emails/frehemgo-hcp-now-approved/images/logo-frehemgo.png" width="250" height="80" alt style="display: inline-block;"></a></td> </tr> <tr> <td align="center" class="email-gutter-desktop-only-30 email-gutter-mobile-20" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-style: italic; font-weight: normal; line-height: 20px; padding-left: 30px; padding-right: 30px;">FREHEMGO<sup style="font-size: 70%; line-height: 1;">®</sup> (denecimig-mima) injection is indicated for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients with hemophilia A (congenital factor VIII deficiency) with or without factor VIII inhibitors.</td> </tr> </table> </td> </tr> <tr> <td align="center" height="20" style="height: 20px; line-height: 20px; border-top: 1px solid #E5E3E6"> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" style="background-color: #b5e3d8;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" class="email-gutter" style="color: #001965; font-family: 'Noto Sans', Apis, 'Arial Black', Arial, Helvetica, sans-serif; font-size: 26px; font-weight: 900; line-height: 30px; padding-bottom: 16px; padding-left: 30px; padding-right: 30px; padding-top: 16px;">NOW APPROVED!</td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" style="background-color: #ffffff;"> <img src="https://emails.hemo.novo.cglife.dev/emails/frehemgo-hcp-now-approved/images/main-image-desktop.jpg" width="670" height="490" alt class="mobile-hide" style="display: block;"> <!--[if !mso]><!--> <div class="mobile-only-content" style="display: none; max-height: 0; max-width: 0; visibility: hidden; width: 0;"> <img src="https://emails.hemo.novo.cglife.dev/emails/frehemgo-hcp-now-approved/images/main-image-mobile.jpg" width="750" height="710" alt class="img-responsive" style="display: block; max-width: 610px;"> </div> <!--<![endif]--> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" class="email-gutter" style="background-color: #F1F8FF; padding-bottom: 16px; padding-left: 30px; padding-right: 30px; padding-top: 36px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" style="color: #001965; font-family: 'Noto Sans', Apis, 'Arial Black', Arial, Helvetica, sans-serif; font-size: 30px; font-style: italic; font-weight: 900; line-height: 34px; text-transform: uppercase;">1 pen. <span class="mobile-break">Once monthly.</span></td> </tr> <tr> <td align="center" style="color: #1E6FD2; font-family: 'Noto Sans', Apis, 'Arial Black', Arial, Helvetica, sans-serif; font-size: 30px; font-style: italic; font-weight: 900; line-height: 34px; padding-bottom: 20px;"><span style="text-transform: uppercase;">Proven bleed protection.</span><sup style="font-size: 60%; line-height: 1;">1,a</sup></td> </tr> <tr> <td align="center" class="email-gutter-desktop-only-90" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: bold; line-height: 26px; padding-bottom: 24px; padding-left: 90px; padding-right: 90px;">The first-and-only, potent FVIIIa mimetic in single-use, prefilled pens.<sup style="font-size: 70%; line-height: 1; white-space: nowrap;">1-3</sup></td> </tr> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 16px; padding-bottom: 16px;"><sup style="font-size: 70%; line-height: 1;">a</sup>Dosing frequency may vary; FREHEMGO<sup style="font-size: 70%; line-height: 1;">®</sup> is available for once-monthly, once-every-2-weeks, and once-weekly dosing.<sup style="font-size: 70%; line-height: 1;">1</sup></td> </tr> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 16px; padding-bottom: 16px;">FVIIIa=Activated Factor VIII.</td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" class="email-gutter" style="padding-bottom: 28px; padding-left: 30px; padding-right: 30px; padding-top: 40px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" class="email-gutter-desktop-only-30" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 26px; padding-bottom: 32px; padding-left: 30px; padding-right: 30px;">FREHEMGO<sup style="font-size: 70%; line-height: 1;">®</sup> (denecimig-mima) injection is now FDA approved for adult and pediatric patients with hemophilia A with or without FVIII inhibitors for routine prophylaxis to prevent or reduce the frequency of bleeding episodes.</td> </tr> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 16px; padding-bottom: 36px;">FVIIIa=Activated Factor VIII.</td> </tr> <tr> <td align="center" style="padding-bottom: 36px;"> <table border="0" cellpadding="0" cellspacing="0"> <tr> <th align="center" class="responsive-th" style="font-weight: normal;"><a href="https://www.novomedlink.com/rare-bleeding-disorders/products/treatments/frehemgo.html" target="_blank" style="background-color: #307FE2; border-radius: 44px; color: #ffffff; display: inline-block; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 20px; mso-padding-alt: 0; padding-bottom: 14px; padding-left: 30px; padding-right: 30px; padding-top: 14px; text-decoration: none; text-underline-color: #307FE2;"><!--[if mso]><i style="mso-font-width:150%; mso-text-raise:140%;" hidden> </i><span style="mso-text-raise:70%;"><![endif]-->Review the data<!--[if mso]></span><i style="mso-font-width:150%;" hidden> ​</i><![endif]--></a> </th> <th align="center" class="col-30 responsive-th" height="24" style="font-weight: normal; height: 24px; line-height: 24px; width: 30px;"> </th> <th align="center" class="responsive-th" style="font-weight: normal;"><a href="#" target="_blank" style="background-color: #ffffff; border: 2px solid #307FE2; border-radius: 44px; color: #307FE2; display: inline-block; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 20px; mso-padding-alt: 0; padding-bottom: 12px; padding-left: 25px; padding-right: 25px; padding-top: 12px; text-decoration: none; text-underline-color: #ffffff;"><!--[if mso]><i style="mso-font-width:150%; mso-text-raise:140%;" hidden> </i><span style="mso-text-raise:70%;"><![endif]-->View the press release<!--[if mso]></span><i style="mso-font-width:150%;" hidden> ​</i><![endif]--></a> </th> </tr> </table> </td> </tr> <tr> <td align="center" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 12px; font-weight: normal; line-height: 16px; padding-bottom: 8px;">Keep scrolling to learn more about FREHEMGO<sup style="font-size: 70%; line-height: 1;">®</sup></td> </tr> <tr> <td align="center"><img src="https://emails.hemo.novo.cglife.dev/emails/frehemgo-hcp-now-approved/images/arrow.png" width="50" height="50" alt style="display: block;"></td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" class="email-gutter" style="padding-bottom: 24px; padding-left: 30px; padding-right: 30px; padding-top: 16px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center"> <table cellpadding="0" cellspacing="0" border="0" width="100%"> <tr> <td align="left" style="color: #307fe2; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 22px; font-weight: bold; line-height: 24px; padding-bottom: 20px;">Important Safety Information for FREHEMGO<sup style="font-size: 60%; line-height: 1;">®</sup></td> </tr> <tr> <td align="left" style="color: #307fe2; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 20px; padding-bottom: 4px;">Contraindications</td> </tr> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; padding-bottom: 4px;">FREHEMGO<sup style="font-size: 70%; line-height: 1;">®</sup> is contraindicated in patients with:</td> </tr> <tr> <td align="left" style="padding-bottom: 16px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td width="8" style="width: 8px;"> </td> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; padding-bottom: 4px; width: 16px;">•</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; padding-bottom: 4px;">Lorem ipsum dolor sit amet, consectetur adipiscing elit.</td> </tr> <tr> <td width="8" style="width: 8px;"> </td> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; width: 16px;">•</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px;">Ut rutrum sollicitudin vulputate. Nunc tincidunt blandit tempor. Maecenas at tincidunt diam. Etiam urna erat, ullamcorper egestas nunc accumsan</td> </tr> </table> </td> </tr> <tr> <td align="left" style="color: #307fe2; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 20px; padding-bottom: 4px;">Warnings & Precautions</td> </tr> <tr> <td align="left" style="padding-bottom: 16px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td width="8" style="width: 8px;"> </td> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; padding-bottom: 4px; width: 16px;">•</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; padding-bottom: 4px;">Lorem ipsum dolor sit amet, consectetur adipiscing elit.</td> </tr> <tr> <td width="8" style="width: 8px;"> </td> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; width: 16px;">•</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px;">Ut rutrum sollicitudin vulputate. Nunc tincidunt blandit tempor. Maecenas at tincidunt diam. Etiam urna erat, ullamcorper egestas nunc accumsan</td> </tr> </table> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" class="email-gutter-70" style="background-color: #E0ECFB; padding-left: 70px; padding-right: 70px; padding-top: 44px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" style="color: #001965; font-family: 'Noto Sans', Apis, 'Arial Black', Arial, Helvetica, sans-serif; font-size: 30px; font-style: italic; font-weight: 900; line-height: 34px; padding-bottom: 32px;">FREHEMGO<sup style="font-size: 60%; line-height: 1;">®</sup>: LONG-LASTING BLEED PROTECTION <span style="color: #307fe2;">IN ONE EASY PEN<sup style="font-size: 60%; line-height: 1;">1</sup></span></td> </tr> </table> </td> </tr> <tr> <td align="center" class="email-gutter-100" style="background-color: #E0ECFB; padding-bottom: 16px; padding-left: 100px; padding-right: 100px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" style="padding-bottom: 8px;"> <table border="0" cellpadding="0" cellspacing="0" class="mobile-width-full"> <tr> <th align="center" valign="top" class="responsive-th col-70" style="font-weight: normal; width: 70px;"><img src="https://emails.hemo.novo.cglife.dev/emails/frehemgo-hcp-now-approved/images/icon-gears.png" width="70" height="70" alt style="display: block;"></th> <th align="center" valign="top" class="responsive-th col-20" height="16" style="font-weight: normal; height: 16px; line-height: 16px; width: 20px;"> </th> <th align="center" valign="top" class="responsive-th" style="font-weight: normal;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" class="text-center" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 22px; font-weight: bold; line-height: 26px; padding-bottom: 8px;">NORMALIZED THROMBIN GENERATION</td> </tr> <tr> <td align="left" class="text-center" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 22px; padding-bottom: 32px;">A potent FVIIIa mimetic that generates thrombin levels in the normal range<sup style="font-size: 70%; line-height: 1;">1</sup></td> </tr> </table> </th> </tr> <tr> <th align="center" valign="top" class="responsive-th col-70" style="font-weight: normal; width: 70px;"><img src="https://emails.hemo.novo.cglife.dev/emails/frehemgo-hcp-now-approved/images/icon-clipboard.png" width="70" height="80" alt style="display: block;"></th> <th align="center" valign="top" class="responsive-th col-20" height="16" style="font-weight: normal; height: 16px; line-height: 16px; width: 20px;"> </th> <th align="center" valign="top" class="responsive-th" style="font-weight: normal;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" class="text-center" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 22px; font-weight: bold; line-height: 26px; padding-bottom: 8px;">SUSTAINED BLEED PROTECTION</td> </tr> <tr> <td align="left" class="text-center mpb-32" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 22px; padding-bottom: 44px;">Up to 31 days with once-monthly dosing<sup style="font-size: 70%; line-height: 1;">1</sup></td> </tr> </table> </th> </tr> <tr> <th align="center" valign="top" class="responsive-th col-70" style="font-weight: normal; width: 70px;"><img src="https://emails.hemo.novo.cglife.dev/emails/frehemgo-hcp-now-approved/images/icon-administration.png" width="70" height="70" alt style="display: block;"></th> <th align="center" valign="top" class="responsive-th col-20" height="16" style="font-weight: normal; height: 16px; line-height: 16px; width: 20px;"> </th> <th align="center" valign="top" class="responsive-th" style="font-weight: normal;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" class="text-center" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 22px; font-weight: bold; line-height: 26px; padding-bottom: 8px;">QUICK, EASY ADMINISTRATION</td> </tr> <tr> <td align="left" class="mpb-32" style="padding-bottom: 20px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" valign="top" width="24" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 22px; padding-bottom: 4px; width: 24px;">•</td> <td align="left" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 22px; padding-bottom: 4px;">Low-volume <span style="white-space: nowrap">(0.8 mL)</span> pens that take <span style="white-space: nowrap"><1 minute</span> to prep and inject<sup style="font-size: 70%; line-height: 1;">1,4,b</sup></td> </tr> <tr> <td align="center" valign="top" width="24" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 22px; padding-bottom: 12px; width: 24px;">•</td> <td align="left" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 22px; padding-bottom: 12px;">93% (N=70) of patients said the FREHEMGO<sup style="font-size: 70%; line-height: 1;">®</sup> pen was either easier or much easier to use than emicizumab vial and syringe (5% said neither more difficult nor easier and 1% said more difficult)<sup style="font-size: 70%; line-height: 1;">4,b</sup></td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px;">For more information, please read the <a href="https://www.novo-pi.com/frehemgo.pdf" style="color: #307fe2; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;" target="_blank">Instructions for Use</a>.</td> </tr> </table> </td> </tr> </table> </th> </tr> <tr> <th align="center" valign="middle" class="responsive-th col-70" style="font-weight: normal; width: 70px;"><img src="https://emails.hemo.novo.cglife.dev/emails/frehemgo-hcp-now-approved/images/icon-safety.png" width="70" height="70" alt style="display: block;"></th> <th align="center" valign="middle" class="responsive-th col-20" height="16" style="font-weight: normal; height: 16px; line-height: 16px; width: 20px;"> </th> <th align="center" valign="middle" class="responsive-th" style="font-weight: normal;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" class="text-center mpb-12" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 22px; font-weight: bold; line-height: 26px; padding-bottom: 8px;">PROVEN SAFETY PROFILE<sup style="font-size: 60%; line-height: 1;">1</sup></td> </tr> </table> </th> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" class="text-center" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 22px; font-weight: normal; line-height: 26px; padding-bottom: 24px;">Across FRONTIER trials<sup style="font-size: 60%; line-height: 1;">1</sup>:</td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <th align="center" class="col-percent-48 responsive-th" style="font-weight: normal; width: 48%;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" style="background-color: #ffffff; border-radius: 10px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" height="16" style="background: linear-gradient(to right, #E1F4EF 0%,#307FE2 100%); background-color: #E1F4EF; border-radius: 10px 10px 0 0; height: 16px; line-height: 16px;"> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" style="padding: 16px 16px 16px 16px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: bold; line-height: 22px; padding-bottom: 8px;">LOW RATE</td> </tr> <tr> <td align="center" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 22px;">of thromboembolic events <br class="mobile-hide"> (XX patients experienced a TE)<sup style="font-size: 70%; line-height: 1;">2</sup></td> </tr> </table> </td> </tr> </table> </td> </tr> </table> </th> <th align="center" class="col-percent-4 responsive-th" style="font-weight: normal; width: 4%;"> <table class="spacer-24" border="0" cellpadding="0" cellspacing="0" width="100%" style="height: 24px; line-height: 24px;"> <tbody> <tr> <td> </td> </tr> </tbody> </table> </th> <th align="center" class="col-percent-48 responsive-th" style="font-weight: normal; width: 48%;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" style="background-color: #ffffff; border-radius: 10px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" height="16" style="background: linear-gradient(to right, #E1F4EF 0%,#307FE2 100%); background-color: #E1F4EF; border-radius: 10px 10px 0 0; height: 16px; line-height: 16px;"> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" style="padding: 16px 16px 16px 16px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: bold; line-height: 22px; padding-bottom: 8px;">NO</td> </tr> <tr> <td align="center" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 22px;">clinical evidence of neutralizing <br class="mobile-hide"> anti-denecimig-mima antibodies<sup style="font-size: 70%; line-height: 1;">1,a</sup></td> </tr> </table> </td> </tr> </table> </td> </tr> </table> </th> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 22px; font-weight: bold; line-height: 26px; padding-bottom: 8px; padding-top: 36px;">Most common adverse reactions (<span style="font-weight: normal">≥</span>10%)<sup style="font-size: 60%; line-height: 1;">1</sup>:</td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 22px; padding-bottom: 12px;">Injection site reactions (12%)</td> </tr> <tr> <td align="left" valign="top"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" valign="top" width="12" style="width: 12px;"> </td> <td align="center" valign="top" width="24" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 22px; padding-bottom: 4px; width: 24px;">•</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 22px; padding-bottom: 4px;">Across >18,000 FREHEMGO<sup style="font-size: 70%; line-height: 1;">®</sup> injections in clinical trials, 1.6% led to injection site reactions<sup style="font-size: 70%; line-height: 1;">2</sup></td> </tr> <tr> <td align="center" valign="top" width="12" style="width: 12px;"> </td> <td align="center" valign="top" width="24" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 22px; padding-bottom: 4px; width: 24px;">•</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 22px; padding-bottom: 4px;">Pain and/or burning reported in 0.2% of injections<sup style="font-size: 70%; line-height: 1;">2</sup></td> </tr> <tr> <td align="center" valign="top" width="12" style="width: 12px;"> </td> <td align="center" valign="top" width="24" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 22px; padding-bottom: 4px; width: 24px;">•</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 22px; padding-bottom: 4px;">All injection site reactions were mild, and none led to discontinuation</td> </tr> </table> </td> </tr> <tr> <td align="left" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-weight: normal; line-height: 22px; padding-bottom: 28px;">Prothrombin fragment 1+2 increased (10%)</td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" class="email-gutter-60" style="background-color: #1E6FD2; padding-bottom: 28px; padding-left: 60px; padding-right: 60px; padding-top: 24px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, 'Arial Black', Arial, Helvetica, sans-serif; font-size: 46px; font-style: italic; font-weight: 900; line-height: 50px;">~9/10</td> </tr> <tr> <td align="center" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, 'Arial Black', Arial, Helvetica, sans-serif; font-size: 22px; font-style: italic; font-weight: 900; line-height: 24px; padding-bottom: 8px;">PATIENTS WERE FREE OF INJECTION SITE REACTIONS</td> </tr> <tr> <td align="center" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 12px; font-weight: normal; line-height: 16px;">while using FREHEMGO<sup style="font-size: 70%; line-height: 1;">®1</sup></td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 16px; padding-bottom: 16px; padding-top: 28px;"><sup style="font-size: 70%; line-height: 1;">a</sup>Of 448 patients, 2 (0.4%) developed transient neutralizing anti-denecimig-mima antibodies without identified clinically significant impact on safety or effectiveness.</td> </tr> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 16px;">TE=thromboembolic event.</td> </tr> </table> </td> </tr> <tr> <td align="center" class="email-gutter-40" style="background-color: #E0ECFB; padding-bottom: 48px; padding-left: 40px; padding-right: 40px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 18px; font-style: italic; font-weight: bold; line-height: 26px; padding-bottom: 20px;">Review key clinical information, dosing and administration details, and practice resources.</td> </tr> <tr> <td align="center"><a href="https://www.novomedlink.com/rare-bleeding-disorders/products/treatments/frehemgo.html" target="_blank" style="background-color: #307FE2; border-radius: 44px; color: #ffffff; display: inline-block; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 20px; mso-padding-alt: 0; padding-bottom: 12px; padding-left: 30px; padding-right: 30px; padding-top: 12px; text-decoration: none; text-underline-color: #307FE2;"><!--[if mso]><i style="mso-font-width:150%; mso-text-raise:140%;" hidden> </i><span style="mso-text-raise:70%;"><![endif]-->Learn more<!--[if mso]></span><i style="mso-font-width:150%;" hidden> ​</i><![endif]--></a> </td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" class="email-gutter-50" style="padding-bottom: 52px; padding-left: 50px; padding-right: 50px; padding-top: 52px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" valign="top" class="responsive-td"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" class="mpt-10 text-center" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 22px; font-weight: bold; line-height: 28px; padding-bottom: 30px; padding-top: 40px;">Have questions? <br>We’re here to help.</td> </tr> <tr> <td align="left" class="mpb-30 text-center"><a href="https://www.novomedlink.com/rare-bleeding-disorders/products/resources/novonordisk-representative.html" target="_blank" style="background-color: #ffffff; border: 2px solid #001965; border-radius: 44px; color: #001965; display: inline-block; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-weight: bold; line-height: 16px; mso-padding-alt: 0; padding-bottom: 8px; padding-left: 30px; padding-right: 30px; padding-top: 8px; text-decoration: none; text-underline-color: #ffffff;"><!--[if mso]><i style="mso-font-width:150%; mso-text-raise:140%;" hidden> </i><span style="mso-text-raise:70%;"><![endif]-->Contact your rep<!--[if mso]></span><i style="mso-font-width:150%;" hidden> ​</i><![endif]--></a> </td> </tr> </table> </td> <td align="center" valign="top" width="280" style="width: 280px;" class="responsive-td"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" class="text-center" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-weight: normal; line-height: 20px; padding-bottom: 20px;">Connect with a Novo Nordisk Rare Blood Therapy Manager in your area. They can help you with:</td> </tr> <tr> <td align="center"> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="max-width: 320px;"> <tr> <td align="left" valign="top" width="30" style="padding-bottom: 10px; width: 30px;"><img src="https://emails.hemo.novo.cglife.dev/emails/frehemgo-hcp-now-approved/images/checkmark-blue.png" width="22" height="22" alt style="display: block;"></td> <td align="left" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-weight: normal; line-height: 20px; padding-bottom: 10px;">Clinical product information</td> </tr> <tr> <td align="left" valign="top" width="30" style="padding-bottom: 10px; width: 30px;"><img src="https://emails.hemo.novo.cglife.dev/emails/frehemgo-hcp-now-approved/images/checkmark-blue.png" width="22" height="22" alt style="display: block;"></td> <td align="left" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-weight: normal; line-height: 20px; padding-bottom: 10px;">Rare bleeding education for patients</td> </tr> <tr> <td align="left" valign="top" width="30" style="padding-bottom: 10px; width: 30px;"><img src="https://emails.hemo.novo.cglife.dev/emails/frehemgo-hcp-now-approved/images/checkmark-blue.png" width="22" height="22" alt style="display: block;"></td> <td align="left" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-weight: normal; line-height: 20px; padding-bottom: 10px;">Resources for starting treatment</td> </tr> <tr> <td align="left" valign="top" width="30" style="padding-bottom: 10px; width: 30px;"><img src="https://emails.hemo.novo.cglife.dev/emails/frehemgo-hcp-now-approved/images/checkmark-blue.png" width="22" height="22" alt style="display: block;"></td> <td align="left" valign="top" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-weight: normal; line-height: 20px; padding-bottom: 10px;">General questions & inquiries</td> </tr> </table> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center"> <table cellpadding="0" cellspacing="0" border="0" width="100%" style="background-color: #001965;"> <tr> <td align="center" class="email-gutter-80" style="padding-bottom: 48px; padding-left: 80px; padding-right: 80px; padding-top: 40px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center" class="mpb-12" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 20px; font-weight: bold; line-height: 28px; padding-bottom: 28px;">Do you have a novoMEDLINK™ account?</td> </tr> <tr> <td align="center" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 22px; padding-bottom: 28px;">Complete a simple registration to receive the latest product news and education from Novo Nordisk.</td> </tr> <tr> <td align="center" style="padding-bottom: 28px;"><a href="https://www.novomedlink.com/account/create.html" target="_blank" style="background-color: #ffffff; border-radius: 44px; color: #001965; display: inline-block; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 20px; mso-padding-alt: 0; padding-bottom: 12px; padding-left: 30px; padding-right: 30px; padding-top: 12px; text-decoration: none; text-underline-color: #ffffff;"><!--[if mso]><i style="mso-font-width:150%; mso-text-raise:140%;" hidden> </i><span style="mso-text-raise:70%;"><![endif]-->Register<!--[if mso]></span><i style="mso-font-width:150%;" hidden> ​</i><![endif]--></a> </td> </tr> <tr> <td align="center" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 22px; padding-bottom: 28px;">With a novoMEDLINK™ account you can:</td> </tr> <tr> <td align="center" class="email-gutter-mobile-20"> <table border="0" cellpadding="0" cellspacing="0" class="col-280" style="width: 280px;"> <tr> <td width="50" style="width: 50px;" align="left" valign="middle"><img src="https://emails.hemo.novo.cglife.dev/emails/frehemgo-hcp-now-approved/images/icon-book.png" width="30" height="40" alt style="display: block;"></td> <td align="left" valign="middle" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 22px;">Order educational materials</td> </tr> <tr> <td width="50" height="20" style="width: 50px; height: 20px; line-height: 20px;"> </td> <td height="20" style="height: 20px; line-height: 20px;"> </td> </tr> <tr> <td width="50" style="width: 50px;" align="left" valign="middle"><img src="https://emails.hemo.novo.cglife.dev/emails/frehemgo-hcp-now-approved/images/icon-list-bullets.png" width="30" height="30" alt style="display: block;"></td> <td align="left" valign="middle" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 22px;">Access the latest product information</td> </tr> <tr> <td width="50" height="20" style="width: 50px; height: 20px; line-height: 20px;"> </td> <td height="20" style="height: 20px; line-height: 20px;"> </td> </tr> <tr> <td width="50" style="width: 50px;" align="left" valign="middle"><img src="https://emails.hemo.novo.cglife.dev/emails/frehemgo-hcp-now-approved/images/icon-updates.png" width="30" height="36" alt style="display: block;"></td> <td align="left" valign="middle" style="color: #FFFFFF; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 22px;">Receive personalized updates</td> </tr> </table> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" class="email-gutter" style="padding-bottom: 16px; padding-left: 30px; padding-right: 30px; padding-top: 36px;"><table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="center"> <table cellpadding="0" cellspacing="0" border="0" width="100%"> <tr> <td align="left" style="color: #307fe2; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 22px; font-weight: bold; line-height: 26px; padding-bottom: 28px;">Indications and Usage for FREHEMGO<sup style="font-size: 60%; line-height: 1;">®</sup></td> </tr> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 22px; padding-bottom: 16px;">Lorem ipsum dolor sit amet, consectetur adipiscing elit. Curabitur eget ante ut eros porttitor semper eget leo. Vivamus quis ex sit amet nibh semper euismod. Etiam aliquet nibh ut molestie tempus. Quisque porttitor rutrum lacus, non aliquet erat ullamcorper vitae. Duis sit amet dictum nisl. Integer nec purus aliquam, interdum nulla ut, varius neque. Sed feugiat convallis lorem a tincidunt.</td> </tr> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 22px; padding-bottom: 32px;">Lorem ipsum dolor sit amet, consectetur adipiscing elit. Curabitur eget ante ut eros porttitor semper eget leo. Vivamus quis ex sit amet nibh semper euismod. Etiam aliquet nibh ut molestie tempus.</td> </tr> <tr> <td align="left" style="color: #307fe2; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 22px; font-weight: bold; line-height: 26px; padding-bottom: 32px;">Important Safety Information (cont’d)</td> </tr> <tr> <td align="left" style="color: #307fe2; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 22px; padding-bottom: 16px;">Warnings and Precautions (cont’d)</td> </tr> <tr> <td align="left" style="padding-bottom: 16px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td width="8" style="width: 8px;"> </td> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; padding-bottom: 4px; width: 16px;">•</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; padding-bottom: 4px;">Lorem ipsum dolor sit amet, consectetur adipiscing elit. Curabitur eget ante ut eros porttitor semper eget leo. Vivamus quis ex sit amet nibh semper euismod. Etiam aliquet nibh ut molestie tempus. Quisque porttitor rutrum lacus, non aliquet erat ullamcorper vitae. Duis sit amet dictum nisl. Integer nec purus aliquam, interdum nulla ut, varius neque. Sed feugiat convallis lorem a tincidunt.</td> </tr> <tr> <td width="8" style="width: 8px;"> </td> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; width: 16px;">•</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px;">Ut rutrum sollicitudin vulputate. Nunc tincidunt blandit tempor. Maecenas at tincidunt diam. Etiam urna erat, ullamcorper egestas nunc accumsan</td> </tr> </table> </td> </tr> <tr> <td align="left" style="color: #307fe2; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 20px; padding-bottom: 16px;">Adverse Reactions</td> </tr> <tr> <td align="left" style="padding-bottom: 16px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td width="8" style="width: 8px;"> </td> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; padding-bottom: 4px; width: 16px;">•</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; padding-bottom: 4px;">Lorem ipsum dolor sit amet, consectetur adipiscing elit. Curabitur eget ante ut eros porttitor semper eget leo. Vivamus quis ex sit amet nibh semper euismod. Etiam aliquet nibh ut molestie tempus. Quisque porttitor rutrum lacus, non aliquet erat ullamcorper vitae. Duis sit amet dictum nisl. Integer nec purus aliquam, interdum nulla ut, varius neque. Sed feugiat convallis lorem a tincidunt.</td> </tr> <tr> <td width="8" style="width: 8px;"> </td> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; width: 16px;">•</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px;">Ut rutrum sollicitudin vulputate. Nunc tincidunt blandit tempor. Maecenas at tincidunt diam. Etiam urna erat, ullamcorper egestas nunc accumsan</td> </tr> </table> </td> </tr> <tr> <td align="left" style="color: #307fe2; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 20px; padding-bottom: 16px;">Drug Interactions</td> </tr> <tr> <td align="left" style="padding-bottom: 16px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td width="8" style="width: 8px;"> </td> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; padding-bottom: 4px; width: 16px;">•</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; padding-bottom: 4px;">Lorem ipsum dolor sit amet, consectetur adipiscing elit. Curabitur eget ante ut eros porttitor semper eget leo. Vivamus quis ex sit amet nibh semper euismod. Etiam aliquet nibh ut molestie tempus. Quisque porttitor rutrum lacus, non aliquet erat ullamcorper vitae. Duis sit amet dictum nisl. Integer nec purus aliquam, interdum nulla ut, varius neque. Sed feugiat convallis lorem a tincidunt.</td> </tr> <tr> <td width="8" style="width: 8px;"> </td> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; width: 16px;">•</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px;">Ut rutrum sollicitudin vulputate. Nunc tincidunt blandit tempor. Maecenas at tincidunt diam. Etiam urna erat, ullamcorper egestas nunc accumsan</td> </tr> </table> </td> </tr> <tr> <td align="left" style="color: #307fe2; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 20px; padding-bottom: 16px;">Use in Specific Populations</td> </tr> <tr> <td align="left" style="padding-bottom: 16px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td width="8" style="width: 8px;"> </td> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; padding-bottom: 4px; width: 16px;">•</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; padding-bottom: 4px;">Lorem ipsum dolor sit amet, consectetur adipiscing elit. Curabitur eget ante ut eros porttitor semper eget leo. Vivamus quis ex sit amet nibh semper euismod. Etiam aliquet nibh ut molestie tempus. Quisque porttitor rutrum lacus, non aliquet erat ullamcorper vitae. Duis sit amet dictum nisl. Integer nec purus aliquam, interdum nulla ut, varius neque. Sed feugiat convallis lorem a tincidunt.</td> </tr> <tr> <td width="8" style="width: 8px;"> </td> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px; width: 16px;">•</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: normal; line-height: 20px;">Ut rutrum sollicitudin vulputate. Nunc tincidunt blandit tempor. Maecenas at tincidunt diam. Etiam urna erat, ullamcorper egestas nunc accumsan</td> </tr> </table> </td> </tr> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 16px; font-weight: bold; line-height: 22px; padding-bottom: 24px; padding-top: 8px;">Please <a href="https://www.novo-pi.com/frehemgo.pdf" target="_blank" style="color: #025edc; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;">click here</a> for FREHEMGO<sup style="font-size: 70%; line-height: 1;">®</sup> Prescribing Information.</td> </tr> </table> </td> </tr> </table></td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="left" class="email-gutter" style="padding-bottom: 24px; padding-left: 30px; padding-right: 30px; padding-top: 12px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: bold; line-height: 14px; padding-bottom: 4px;">References:</td> </tr> <tr> <td align="left"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px; padding-bottom: 2px; width: 16px;">1.</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px; padding-bottom: 2px;"><span class="default-blue-text">FREHEMGO [package insert]. Plainsboro, NJ; Novo Nordisk Inc.</span></td> </tr> <tr> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px; padding-bottom: 2px; width: 16px;">2.</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px; padding-bottom: 2px;"><span class="default-blue-text">Østergaard H, Lund J, Greisen PJ, et al. A factor VIIIa-mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice. Blood. 2021;138(14):1258-1268.</span></td> </tr> <tr> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px; padding-bottom: 2px; width: 16px;">3.</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px; padding-bottom: 2px;"><span class="default-blue-text">Lentz SR, Chowdary P, Gil L, et al. FRONTIER1: a partially randomized phase 2 study assessing the safety, pharmacokinetics, and pharmacodynamics of Mim8, a factor VIIIa mimetic. <i>J Thromb Haemost</i>. 2024;22(4):990-1000. </span></td> </tr> <tr> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px; padding-bottom: 2px; width: 16px;">4.</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px; padding-bottom: 2px;"><span class="default-blue-text">Lauritzen B, Bjelke M, Björkdahl O, et al. A novel next-generation FVIIIa mimetic, Mim8, has a favorable safety profile and displays potent pharmacodynamic effects: results from safety studies in cynomolgus monkeys. <i>J Thromb Haemost</i>. 2022;20(6):1312-1324.</span></td> </tr> <tr> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px; padding-bottom: 2px; width: 16px;">5.</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px; padding-bottom: 2px;"><span class="default-blue-text">Data on file. Novo Nordisk Inc; Plainsboro, NJ.</span></td> </tr> <tr> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px; padding-bottom: 2px; width: 16px;">6.</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px; padding-bottom: 2px;"><span class="default-blue-text">FRONTIER2 publication (to be published)</span></td> </tr> <tr> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px; padding-bottom: 2px; width: 16px;">7.</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px; padding-bottom: 2px;"><span class="default-blue-text">FRONTIER3 publication (to be published)</span></td> </tr> <tr> <td align="left" valign="top" width="16" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px; padding-bottom: 2px; width: 16px;">8.</td> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 14px; padding-bottom: 2px;"><span class="default-blue-text">FRONTIER4 publication (to be published)</span></td> </tr> </table> </td> </tr> </table> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" class="email-container" style="background-color: #ffffff; width: 670px;"> <tr> <td align="center" class="email-gutter" style="padding-bottom: 20px; padding-left: 30px; padding-right: 30px; padding-top: 20px;"> <table border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td valign="top"> <table cellpadding="0" cellspacing="0" border="0" width="100%" style="border-top: 1px solid #979797"> <!-- Pricing Block Start --> <tr> <td align="left" class="pricing-block-text" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 14px; font-style: italic; font-weight: bold; line-height: 18px; padding-bottom: 12px; padding-top: 24px;"> Colorado prescriber disclosure. </td> </tr> <!--Pricing Block End --> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 12px; font-weight: normal; line-height: 16px; padding-top: 12px;"><span class="default-blue-link-text">Please do not respond to this email. If you would like to contact us, please <a href="https://www.novonordisk-us.com/contact-us.html" target="_blank" style="color: #025edc; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;">click here</a> or call <span class="default-blue-link-text" style="white-space: nowrap;">1‑877‑744‑2579</span>.</span></td> </tr> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 12px; font-weight: normal; line-height: 16px; padding-top: 15px;">UNSUBSCRIBE NOTICE</td> </tr> <tr> <td align="left" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 12px; font-weight: normal; line-height: 16px;"><span class="default-blue-text">If you no longer want to receive communications from Novo Nordisk, <a href="https://example.com/unsubscribe" target="_blank" style="color: #025edc; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;">click here</a> to unsubscribe. You also may call us at <span class="default-blue-link-text" style="white-space: nowrap;">1-877-744-2579</span> or send us a letter that includes your full contact information (eg, name, email address, phone) to Novo Nordisk, 800 Scudders Mill Road, Plainsboro, New Jersey 08536. To better understand how Novo Nordisk values your privacy, see our <a href="https://www.novonordisk-us.com/privacy-notice.html" target="_blank" style="color: #025edc; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; text-decoration: underline;">Privacy Statement</a>.</span></td> </tr> </table> </td> </tr> <tr> <td valign="bottom" style="padding-bottom: 20px; padding-top: 20px;"> <table cellpadding="0" cellspacing="0" border="0" align="left" width="100%"> <tr> <td align="left" valign="middle" style="color: #001965; font-family: 'Noto Sans', Apis, Arial, Helvetica, sans-serif; font-size: 11px; font-weight: normal; line-height: 16px;"><span class="default-blue-text">FREHEMGO<sup style="font-size: 70%; line-height: 1;">®</sup> is a registered trademark of Novo Nordisk Health Care AG.<br>novoMEDLINK™ is a trademark of Novo Nordisk <span style="white-space: nowrap;">A/S.</span><br>Novo Nordisk is a registered trademark of Novo Nordisk <span style="white-space: nowrap;">A/S.</span><br>© 2026 Novo Nordisk All rights reserved. <span style="white-space: nowrap;">US26DENE00013</span> <span style="white-space: nowrap;">September 2026</span></span></td> <td align="right" valign="middle" class="col-110 mobile-hide" style="width: 110px;"><img src="https://emails.hemo.novo.cglife.dev/emails/frehemgo-hcp-now-approved/images/logo-novo-nordisk.png" width="100" height="36" alt="Novo Nordisk logo." style="display: block;"></td> </tr> </table> <!--[if !mso]><!--> <div class="mobile-only-content" style="display: none; max-height: 0; max-width: 0; visibility: hidden; width: 0;"> <table cellpadding="0" cellspacing="0" border="0" width="100%"> <tr> <td align="center" valign="top" style="padding-top: 12px;"><img src="https://emails.hemo.novo.cglife.dev/emails/frehemgo-hcp-now-approved/images/logo-novo-nordisk.png" width="100" height="36" alt="Novo Nordisk logo." style="display: block;"></td> </tr> </table> </div> <!--<![endif]--> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> </center> </body> </html>